Diverse pathophysiological processes converge on network disruption in mania
نویسندگان
چکیده
منابع مشابه
Diverse type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network
Type 2 Diabetes (T2D) constitutes a global health burden. Efforts to uncover predisposing genetic variation have been considerable, yet detailed knowledge of the underlying pathogenesis remains poor. Here, we constructed a T2D phenotypic-linkage network (T2D-PLN), by integrating diverse gene functional information that highlight genes, which when disrupted in mice, elicit similar T2D-relevant p...
متن کاملTreatment of acute mania with methylphenidate: therapeutic approach based on a new pathophysiological model.
The initial treatment for patients with acute mania represents a significant clinical challenge, given that treatments for mania symptom control usually take several days to start acting. Most treatments available for the manic phase of bipolar disorder are sedatives, to lower the hyperactivity and excitation that patients with mania present. However, recent observations indicate that these sym...
متن کاملMania-like behavior induced by disruption of CLOCK.
Circadian rhythms and the genes that make up the molecular clock have long been implicated in bipolar disorder. Genetic evidence in bipolar patients suggests that the central transcriptional activator of molecular rhythms, CLOCK, may be particularly important. However, the exact role of this gene in the development of this disorder remains unclear. Here we show that mice carrying a mutation in ...
متن کاملArchitecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase
Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis. Viral proteins targeting UDG, such as the bacteriophage proteins ugi, and p56, and the HIV-1 protein Vpr, share no sequence similarity, and are not structurally homologous. Such diversit...
متن کاملA Simple Cell-Based Assay Reveals That Diverse Neuropsychiatric Risk Genes Converge on Primary Cilia
Human genetic studies are beginning to identify a large number of genes linked to neuropsychiatric disorders. It is increasingly evident that different genes contribute to risk for similar syndromes and, conversely, the same genes or even the same alleles cross over traditional diagnostic categories. A current challenge is to understand the cellular biology of identified risk genes. However, mo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Affective Disorders
سال: 2019
ISSN: 0165-0327
DOI: 10.1016/j.jad.2018.10.087